electroCore LLC

About gammaCore

Treat migraine and cluster headache at the core

  • gammaCore: Novel, non-invasive vagus nerve stimulation (nVNS) delivered by a patient friendly, hand-held device
  • Completely non-invasive therapy stimulates the cervical branch of the vagus nerve. No surgery. No invasive procedure
  • VNS demonstrates the ability to suppress high glutamate levels in the trigeminal nucleaus caudalis (TNC), which may be the pain-blocking mechanism of nVNS1

The next frontier of headache pain management

  • Global clinical program: 3 randomized clinical trials completed, 3 additional studies in progress. One of the largest clinical programs in headache
  • Non-pharmacologic, flexible treatment option with a role in both acute and preventative treatment
  • Side effects are primarily local, mild, and transient

gammaCore: bringing the clinical potential of nVNS to life

  • gammaCore makes nVNS practical, safe, and flexible
  • Avoids the surgery-related adverse effects and costs of implantable neuromodulating devices and potentially limits adverse effects related to continuous on-off stimulation2,3
  • gammaCore is administered with a hand-held device, about the size of a mobile phone that generates a unique electrical signal. A conductive gel is applied on the stimulation surfaces of the device and it is placed on the neck. Each dose takes approximately 2 minutes to administer (you may require more than one dose per treatment).

Learn more about non-invasive vagus nerve stimulation (nVNS) and its role in treating headache disorders.


1. Oshinsky ML, Murphy AL, Hekierski H Jr., Cooper M, Simon BJ. Non-invasive vagus nerve stimulation as treatment for trigeminal allodynia. Pain (2014), doi:
2. Goadsby PJ, Grosberg BM, Mauskop, Cady R, Simmons KA. Effect of noninvasive vagus nerve stimulation on acute migraine: an open-label pilot study [published online March 7, 2014]. Cephalalgia. doi:10.1177/0333102414524494.
3. Jürgens TP, Leone M. Pearls and pitfalls: neurostimulation in headache. Cephalalgia. 2013;33(8):512-525