Novel, non-invasive vagus nerve stimulation (nVNS) with gammaCore
The therapeutic role of implanted vagus nerve stimulation is well established in several disorders related to autonomic dysfunction.1–4
In an animal model, excessive glutamate levels in the trigeminal nucleus caudalis (TNC) are believed to be a marker for increased trigeminal pain.5
In an animal model, non-invasive vagus nerve stimulation (nVNS) demonstrates the ability to suppress high glutamate levels in the TNC, which may be the mechanism by which it alleviates the symptoms of headache.5
gammaCore nVNS Mechanism of Action5
An animal model of trigeminal allodynia simulating the hypersensitivity found in patients with migraine was used to examine the mechanism of action of nVNS5
nVNS increased periorbital pain threshold
- Rats were given prostaglandin E2 infusion 3 times a week for 3 to 4 weeks to produce matching patterns of migraine pain5
- Following 2 minutes of nVNS, periorbital pain threshold increased 4.7 ± 1.0 times within 5 minutes (vs pre-stimulation levels) and was maintained for 3.5 hours after nVNS5
nVNS decreased trigeminal nociceptive stimulation by suppressing the rise in glutamate5
- Glyceryl trinitrate (GTN) treatment administered to allodynic rats caused a 7.7 ± 0.9-fold increase in extracellular glutamate5
- 2 minutes of nVNS plus GTN treatment resulted in only a 2.3 ± 0.4-fold increase in extracellular glutamate in allodynic rats and was not significantly different from the glutamate increases in naïve rats after GTN (1.9 ± 0.1-fold increase)5
- Delayed nVNS (120 minutes after GTN in allodynic rats) effected a rapid glutamate level decrease from 4.8 ± 2.4-fold to 1.9 ± 0.9-fold5
gammaCore Augmented Reality (AR) Application
This application was designed to create an interactive format to learn more about primary headaches and the proposed mechanism of action of the gammaCore® device.
Download and print the gammaCore “trackable” image designed specifically to be scanned by the AR application. Click here.
Download the app from the App Store. Click here to download.
After you launch the app, follow the on-screen instructions and point your mobile device camera at the gammaCore “trackable” image to experience the AR effect.
gammaCore: Clinical Results